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Literature summary extracted from

  • Liao, W.C.; Liao, C.K.; Tseng, T.J.; Ho, Y.J.; Chen, Y.R.; Lin, K.H.; Lai, T.J.; Lan, C.T.; Wei, K.C.; Liu, C.H.
    Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability (2020), Oncogenesis, 9, 9 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.175 gene CHSY1, quantitative RT-PCR enzyme expressiona analysis Homo sapiens
2.4.1.226 gene CHSY1, quantitative RT-PCR enzyme expressiona analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.175 additional information both CHSY1 expression and CS56 staining are dramatically decreased in CHSY1-silenced cells Homo sapiens
2.4.1.226 additional information both CHSY1 expression and CS56 staining are dramatically decreased in CHSY1-silenced cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.175 cytoplasm
-
 Homo sapiens 5737
-
2.4.1.175 extracellular
-
 Homo sapiens
-
-
2.4.1.175 additional information CHSY1 is mainly expressed in the paranuclear cytoplasm and strong CS56 staining in the extracellular space, plasma membrane, and cytoplasm of control cells Homo sapiens
-
-
2.4.1.175 plasma membrane
-
 Homo sapiens 5886
-
2.4.1.226 cytoplasm
-
 Homo sapiens 5737
-
2.4.1.226 extracellular
-
 Homo sapiens
-
-
2.4.1.226 additional information CHSY1 is mainly expressed in the paranuclear cytoplasm and strong CS56 staining in the extracellular space, plasma membrane, and cytoplasm of control cells Homo sapiens
-
-
2.4.1.226 plasma membrane
-
 Homo sapiens 5886
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.175 Homo sapiens Q86X52
-
-
2.4.1.226 Homo sapiens Q86X52
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.175 A-172 cell
-
 Homo sapiens
-
2.4.1.175 astrocytoma cell
-
 Homo sapiens
-
2.4.1.175 GL-261 cell
-
 Homo sapiens
-
2.4.1.175 glioma cell CHSY1 is frequently upregulated in glioblastoma and correlates with high tumor grade and poor survival Homo sapiens
-
2.4.1.175 oligodendroglioma cell
-
 Homo sapiens
-
2.4.1.175 U-118MG cell
-
 Homo sapiens
-
2.4.1.226 A-172 cell
-
 Homo sapiens
-
2.4.1.226 astrocytoma cell
-
 Homo sapiens
-
2.4.1.226 GL-261 cell
-
 Homo sapiens
-
2.4.1.226 glioma cell CHSY1 is frequently upregulated in glioblastoma and correlates with high tumor grade and poor survival Homo sapiens
-
2.4.1.226 oligodendroglioma cell
-
 Homo sapiens
-
2.4.1.226 U-118MG cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.4.1.175 bifunctional CS synthase
-
 Homo sapiens
2.4.1.175 chondroitin sulfate synthase 1
-
 Homo sapiens
2.4.1.175 CHSY1
-
 Homo sapiens
2.4.1.175 CS synthase 1
-
 Homo sapiens
2.4.1.226 bifunctional CS synthase
-
 Homo sapiens
2.4.1.226 chondroitin sulfate synthase 1
-
 Homo sapiens
2.4.1.226 CHSY1
-
 Homo sapiens
2.4.1.226 CS synthase 1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.1.175 Homo sapiens CHSY1 is frequently upregulated in human glioma up
2.4.1.226 Homo sapiens CHSY1 is frequently upregulated in human glioma up

General Information

EC Number General Information Comment Organism
2.4.1.175 malfunction correlation between clinicopathological features and expression of CS synthases in glioma patients. We explore the changes of cell surface CS and its contribution to malignant growth of glioma cells, by manipulating CS Synthase 1 (CHSY1) expression. Overexpression of CHSY1 inhibits PDGF-triggered decrease in PDGFRA levels, whereas CHSY1 knockdown accelerates PDGFRA decrease following PDGF stimulation. PDGFRA is highly expressed on the cell membrane of CHSY1-overexpressing GL261 tumor tissue sections. PDGFRA inhibition reverses CHSY1-mediated tumor growth in vitro and in vivo Homo sapiens
2.4.1.175 metabolism the biosynthesis of chondroitin sulfate (CS) chains begins with the formation of a link between N-acetylgalactosamine (GalNAc) and a common tetrasaccharide structure at a serine residue on the core protein. The next step (polymerization) is catalyzed by a group of bifunctional enzymes that have beta1-3 glucuronosyltransferase and beta1-4 N-acetylgalactosaminyltransferase activities. A single CS chain can consist of up to 50 repeating GlcA-GalNAc subunits, which are modified with sulfate groups at various positions. Three bifunctional CS synthases, CHSY1, CHPF (CHSY2), and CHSY3, control polymerization of CS chains Homo sapiens
2.4.1.175 physiological function CHSY1 selectively modulates platelet derived growth factor receptor alpha (PDGFRA) signaling, and that survival of a mouse model of a CHSY1-expressing tumor is increased by using a PDGFR inhibitor. CHSY1 mediates CS formation in glioma cells. CHSY1 is a crucial enzyme to modulate CS formation in GBM cells in vitro. CHSY1 is a crucial enzyme to modulate CS formation in GBM cells in vitro. CHSY1 selectively regulates the PDGFRA pathway and enhances PDGFRA protein stability in glioblastoma cells Homo sapiens
2.4.1.226 malfunction correlation between clinicopathological features and expression of CS synthases in glioma patients. The changes of cell surface CS and its contribution to malignant growth of glioma cells are analyzed, by manipulating CS synthase 1 (CHSY1) expression. Overexpression of CHSY1 inhibits PDGF-triggered decrease in PDGFRA levels, whereas CHSY1 knockdown accelerates PDGFRA decrease following PDGF stimulation. PDGFRA is highly expressed on the cell membrane of CHSY1-overexpressing GL261 tumor tissue sections. PDGFRA inhibition reverses CHSY1-mediated tumor growth in vitro and in vivo Homo sapiens
2.4.1.226 metabolism the biosynthesis of chondroitin sulfate (CS) chains begins with the formation of a link between N-acetylgalactosamine (GalNAc) and a common tetrasaccharide structure at a serine residue on the core protein. The next step (polymerization) is catalyzed by a group of bifunctional enzymes that have beta1-3 glucuronosyltransferase and beta1-4 N-acetylgalactosaminyltransferase activities. A single CS chain can consist of up to 50 repeating GlcA-GalNAc subunits, which are modified with sulfate groups at various positions. Three bifunctional CS synthases, CHSY1, CHPF (CHSY2), and CHSY3, control polymerization of CS chains Homo sapiens
2.4.1.226 physiological function CHSY1 selectively modulates platelet derived growth factor receptor alpha (PDGFRA) signaling, and that survival of a mouse model of a CHSY1-expressing tumor is increased by using a PDGFR inhibitor. CHSY1 mediates CS formation in glioma cells. CHSY1 is a crucial enzyme to modulate CS formation in GBM cells in vitro. CHSY1 selectively regulates the PDGFRA pathway and enhances PDGFRA protein stability in glioblastoma cells Homo sapiens